\documentclass{article}
\usepackage{multirow}

\begin{document}

\begin{table}
	\centering
	\begin{tabular}{ccc}
		\multicolumn{2}{c}{\multirow[t]{2}{*}[-.77ex]{\Large{A}}} & B \\
		  &                                                       & C \\
		D & E                                                     & F \\
	\end{tabular}
	\caption{Bla bla}
\end{table}

\end{document}
